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Conservation of gene expression patterns between the amniotic and nasal epithelium at birth

Amniotic epithelial cells are fetal-derived stem cells, capable of differentiating into all three germ layers, including mature epithelial cell populations. Here, we hypothesised that the amniotic epithelium might serve as a surrogate tissue source for investigating transcriptional profiles in the respiratory epithelium of newborns.

Citation:
Hancock DG, Agudelo-Romero SP, Kicic-Starcevich E, Lim J, Karpievitch YV, Zhang G, Martino DJ, Kicic A, Iosifidis T, Stick S. Conservation of gene expression patterns between the amniotic and nasal epithelium at birth. ERJ Open Res. 2025;11(6).

Keywords:
Epithelial cells; anmiotic epithelium; newborn; gene expression

Abstract:
Amniotic epithelial cells are fetal-derived stem cells, capable of differentiating into all three germ layers, including mature epithelial cell populations. Here, we hypothesised that the amniotic epithelium might serve as a surrogate tissue source for investigating transcriptional profiles in the respiratory epithelium of newborns.