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National Hybrid Closed-Loop Outpatient Trial

The national Hybrid Closed-Loop Outpatient Trial will test the use of an automated insulin delivery system to see if it is better at optimising blood glucose levels than standard therapy.

Role of stem cell precursors in tissues

We have recently published a paper identifying precursor populations in peripheral lung (2017), and have also discovered that these populations can be found in multiple tissues.

Western Australian DNA and Longitudinal Serum Bank for Weight Regulation

This resource will allow researchers to carry out studies which will look at the genetic causes of excessive weight gain and identify biomarkers

Attenuation of maternal inflammatory responses during pregnancy to promote normal immune and behavioral outcomes in the offspring

This study will identify how the immune system contributes to neurodevelopmental outcomes and will investigate the use of an agent from traditional medicines.

A Database of the Complications of Obesity in Children

The Obesity Database records the characteristics and medical complications of children with obesity who present to treatment at Princess Margaret Hospital

The impact of Influenza infection during early life on immune development

This study will investigate the why disease is worse in infants and how early life viral infection impacts the developing immune system.

Western Australian Children’s Diabetes Database

This register was established at Princess Margaret Hospital in 1987 which stores data on all consenting patients attending the hospital’s diabetes clinic.

Longitudinal Type 1 and 2 Diabetes Plasma and Serum Repository

The Serum & Plasma bank was established to provide a store of samples from subjects with diabetes as well as their families.

Diabetes Translational Research

The year 2013 saw the progress in our research from purely lab-based studies towards taking a step closer to translational research.

Mapping changes in immune cell populations in gestational tissues over the course of pregnancy

This is a strategic “pilot” project in which we are seeking basic information on the immune cell content of gestational tissues.

Early biomarkers predictive of autism

This study aims to investigate the cellular and molecular profiles of the immune system in infants at high/low risk for Autism, as determined through clinical assessment.

Epigenetic changes underpinning allergen sensitization: a twin-based study

We are studying immune cells from identical twins of which one suffers and one does not suffer from allergic disease to identify specific mechanisms that may play important roles in disease development.

Can exercise training Improve health in young people with type 2 diabetes?

We are studying exercise in young people with T2DM and obese young people at risk of developing type 2 diabetes

Finding the cellular explanation for recurrent asthma exacerbations

This study is designed to identify the specific unique immune cell response that occurs in these children with recurrent disease.

Epidemiology of T2DM in childhood and associated disease complications

Investigating the incidence of childhood Type 2 Diabetes in the Western Australian community

The cellular effects of estrogen on allergic asthma

The study aims to identify the mechanism for this so that this knowledge can be used to better treat asthma and allergies in both males and females.