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The Human Phenotype Ontology in 2021The Human Phenotype Ontology was launched in 2008 to provide a comprehensive logical standard to describe and computationally analyze phenotypic abnormalities found in human disease. The HPO is now a worldwide standard for phenotype exchange. The HPO has grown steadily since its inception due to considerable contributions from clinical experts and researchers from a diverse range of disciplines. Here, we present recent major extensions of the HPO for neurology, nephrology, immunology, pulmonology, newborn screening, and other areas.
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T-cell responses against rhinovirus species A and C in asthmatic and healthy childrenInfections by RV species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other respiratory disease.
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Dysfunctional gut microbiome networks in childhood ige‐mediated food allergyThe development of food allergy has been reported to be related with the changes in the gut microbiome, however the specific microbe associated with the pathogenesis of food allergy remains elusive. This study aimed to comprehensively characterize the gut microbiome and identify individual or group gut microbes relating to food-allergy using 16S rRNA gene sequencing with network analysis.
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Association Between Family Characteristics and the Effect of Timing of Regular Egg Introduction in Infant Egg AllergyA recent systematic review of 5 randomized clinical trials, found that early egg introduction was associated with reduced egg allergy.
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Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental AllergyThe pathogenesis of asthma continues to be a major topic of interest to our authors with reviews and original papers on the role of viruses, mechanisms of...
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Retrospective Case-Control Study of 2017 G2P[4] Rotavirus Epidemic in Rural and Remote AustraliaA widespread G2P[4] rotavirus epidemic in rural and remote Australia provided an opportunity to evaluate the performance of Rotarix and RotaTeq rotavirus vaccines, ten years after their incorporation into Australia's National Immunisation Program.
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Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infectionEarly aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection
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A marked shift in innate and adaptive immune response in chinese immigrants living in a western environmentThere is a marked shift in innate and adaptive immune responses in Chinese immigrants after living in a Western environment for several years
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IgE and T-cell responses to house dust mite allergen componentsRecent studies with synthetic peptides representing allergens and non-allergenic house dust mite proteins now offer new research avenues on HDM induced immune responses
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Species-Specific and Cross-Reactive IgG1 Antibody Binding to Viral Capsid Protein 1 (VP1) Antigens of Human Rhinovirus Species A, B and CHuman rhinoviruses (HRV) are associated with upper and lower respiratory illnesses, including severe infections causing hospitalization in both children...