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Research
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease riskLung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups.
Research
Ventilatory response and stability of oxygen saturation during a hypoxic challenge in very preterm infantsPreterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge.
Research
Associations between respiratory and vascular function in early childhoodThe link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity.
Research
Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteriaStreptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae is associated with otitis media
Research
Exhaled breath temperature in healthy children is influenced by room temperature and lung volumeExhaled breath temperature (EBT) has been proposed for the non-invasive assessment of airway inflammation
Research
Changes in lung volume during spells in children with Tetralogy of Fallot under general anesthesiaTo describe the changes in end-expiratory lung volume and ventilation inhomogeneities during spells in three children with Tetralogy of Fallot.
Research
Lung function testing in preschool-aged children with cystic fibrosis in the clinical settingThis study investigated the nature and prevalence of atypical pain responses in Rett syndrome and their relationships with specific MECP2 mutations.
News & Events
My child is wheezing – what should I do?Almost 50 per cent of preschool children will experience at least one episode of wheeze, a whistling sound produced by the airways during breathing.
News & Events
Can a simple urine test predict asthma? New study aims to find outThe Kids Research Institute Australia researchers are investigating whether a simple urine test could predict whether young children with wheezing symptoms will go on to develop asthma.
News & Events
Premmie twins defy the oddsWhen Samuel and James Considine were born in October 2003, perilously close to what the medical world describes as the limit of viability, each weighed just 700 grams and could fit into the palm of their father’s hand.